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丙泊酚是临床最常用的静脉麻醉药之一,其作用特点是起效迅速、作用时间短、苏醒完全。但是临床应用中,不同个体间丙泊酚的药代动力学存在较大的差异。近年来随着高原医疗卫生事业不断发展,高原地区的手术量呈稳步增长的趋势。由于高原特殊的地理及气候环境对麻醉药物在体内的吸收、分布、代谢和排泄的影响,高原地区合理使用麻醉药物引起了相关学者的关注。本文从药物代谢的基本原理方面对丙泊酚药代动力学及高原环境对其的影响进行综述,为高原地区临床麻醉合理用药提供理论依据,为后续开展相关临床和基础实验提供支持。
Abstract：Propofol, a fast onset, short-acting, wakeing up completely anesthetic, is the most commonly used intravenous anesthetic. However, during the clinical use of propofol, the pharmacokinetic response of propofol varies greatly among individuals. With the continuous development of medical and health services in plateau areas, the number of patients receiving surgeries shows a stable increasing trend. The special geographical and climatic environment of plateau areas affects the absorption, distribution, metabolism and excretion of drugs in vivo. Therefore rational use of narcotic drugs has aroused scholars' attentions. This paper reviews the research on the pharmacokinetics of propofol from the basic principles of drug metabolism and the influence of the plateau environment, which provide a theoretical basis for the rational use of narcotic drugs in clinical practice in the plateau area and is conducive to the subsequent development of related clinical and basic experiments.
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基本信息:
中图分类号:R614
引用信息:
[1]李丽君,刘政,王升,等.高原环境对丙泊酚药代动力学影响机制的研究进展[J].麻醉安全与质控,2021,5(03):181-185.
基金信息:
国家自然科学基金(81660197); 青海省自然科学基金(2019-ZJ-930)
2021-05-12
2021-05-12